Synthesis and antimalarial activity of febrifugine derivatives.
نویسندگان
چکیده
The regioisomers (2a,b) of the piperidine ring of febrifugine (1a) and isofebrifugine (1b) were synthesized from 4-allyl-3-piperidone (5). Reduction of 5 afforded a mixture of the trans and cis alcohols (6a,b) without diastereoselectivity; this result differentiated it from the reduction of 2-allyl-3-piperidone (14). The antimalarial activity of 2a,b and related compounds was tested.
منابع مشابه
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عنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 49 6 شماره
صفحات -
تاریخ انتشار 2001